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1

Lipoprotein lipase: structure, function and mechanism of action

Silvia Santamarina-Fojo, H. Bryan Brewer

Journal:

International Journal of Clinical & Laboratory Research

Year:

1994

Language:

english

File:

PDF, 464 KB

english, 1994

2

Adenoviral expression of human lecithin-cholesterol acyltransferase in nonhuman primates leads to an antiatherogenic lipoprotein phenotype by increasing high-density lipoprotein and lowering low-density lipoprotein

Marcelo J.A. Amar, Robert D. Shamburek, Boris Vaisman, Catherine L. Knapper, Bernhard Foger, Robert F. Hoyt Jr, Silvia Santamarina-Fojo, Hollis B. Brewer Jr, Alan T. Remaley

Journal:

Year:

2009

Language:

english

File:

PDF, 330 KB

english, 2009

3

New insights into the role of the adenosine triphosphate–binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport

H.Bryan Brewer Jr., Silvia Santamarina-Fojo

Journal:

The American Journal of Cardiology

Year:

2003

Language:

english

File:

PDF, 519 KB

english, 2003

4

Clinical significance of High-Density lipoproteins and the development of atherosclerosis: focus on the role of the adenosine triphosphate–Binding cassette protein A1 transporter

H.Bryan Brewer Jr., Silvia Santamarina-Fojo

Journal:

The American Journal of Cardiology

Year:

2003

Language:

english

File:

PDF, 291 KB

english, 2003

5

Heterozygous apolipoprotein C-II deficiency: lipoprotein and apoprotein phenotype and Rsal restriction enzyme polymorphism in the Apo C'IIPadova kindred

C. GABELLI, C. BILATO, S. SANTAMARINA-FOJO, S. MARTINI, H. B. BREWER JR, G. CREPALDI, G. BAGGIO

Journal:

European Journal of Clinical Investigation

Year:

1993

Language:

english

File:

PDF, 692 KB

english, 1993

6

Effects of FXR in foam-cell formation and atherosclerosis development

Grace L. Guo, Silvia Santamarina-Fojo, Taro E. Akiyama, Marcelo J.A. Amar, Beverly J. Paigen, Bryan Brewer Jr., Frank J. Gonzalez

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2006

Language:

english

File:

PDF, 765 KB

english, 2006

7

Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet

Federica Basso, Marcelo J. Amar, Elke M. Wagner, Boris Vaisman, Beverly Paigen, Silvia Santamarina-Fojo, Alan T. Remaley

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 445 KB

english, 2006

8

Comparative genome analysis of potential regulatory elements in the ABCG5–ABCG8 gene cluster

Alan T Remaley, Samantha Bark, Avram D Walts, Lita Freeman, Sergey Shulenin, Tarmo Annilo, Eric Elgin, Hope E Rhodes, Charles Joyce, Michael Dean, Silvia Santamarina-Fojo, H.Bryan Brewer Jr.

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 229 KB

english, 2002

9

The ABCA1 transporter functions on the basolateral surface of hepatocytes

Edward B Neufeld, Steven J Demosky Jr., John A Stonik, Christian Combs, Alan T Remaley, Nicolas Duverger, Silvia Santamarina-Fojo, H.Bryan Brewer Jr.

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 366 KB

english, 2002

10

A normal rate of cellular cholesterol removal can be mediated by plasma from a patient with familial lecithin–cholesterol acyltransferase (LCAT) deficiency

Annie M Bérard, Michel Clerc, Bryan Brewer Jr., Silvia Santamarina-Fojo

Journal:

Clinica Chimica Acta

Year:

2001

Language:

english

File:

PDF, 184 KB

english, 2001

11

Adenoviral delivery of low-density lipoprotein receptors to hyperlipidemic rabbits: Receptor expression modulates high-density lipoproteins

David R. Brown, Margaret E. Brousseau, Robert D. Shamburek, Glenda D. Talley, Susan Meyn, Stephen J. Demosky Jr, Silvia Santamarina-Fojo, H.Bryan Brewer Jr, Jeffrey M. Hoeg

Journal:

Year:

1996

Language:

english

File:

PDF, 3.17 MB

english, 1996

12

Overexpression of human lecithin-cholesterol acyl transferase in transgenic rabbits leads to hyperalphalipoproteinemia

J.M. Hoeg, S. Santamarina-Fojo, B.L. Vaisman, S.J. Demosky Jr, R.F. Hoyt Jr, S.H. Feldman, G. Talley, H.B. Brewer Jr

Journal:

Atherosclerosis

Year:

1994

Language:

english

File:

PDF, 148 KB

english, 1994

13

LPL and hepatic lipase: new insights into enzyme function

S. Santamarina-Fojo

Journal:

Atherosclerosis

Year:

1994

Language:

english

File:

PDF, 158 KB

english, 1994

14

Transgenic mice expressing human lecithin-cholesterol acyltransferase (LCAT)

H.-G. Klein, B. Vaismann, D. Seidel, H.B. Brewer Jr., S. Santamarina-Fojo

Journal:

Atherosclerosis

Year:

1995

Language:

english

File:

PDF, 102 KB

english, 1995

15

2P-0451 The ABCA1 transporter modulates late endocytic trafficking

Neufeld, E., Stonik, J.A., Demosky, S.J., Knapper, C., Remaley, A.T., Santamarina-Fojo, S., Brewer, H.B.

Journal:

Atherosclerosis Supplements

Year:

2003

Language:

english

File:

PDF, 78 KB

english, 2003

16

Hepatic Lipase, Lipoprotein Metabolism, and Atherogenesis

Santamarina-Fojo, S.

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

2004

Language:

english

File:

PDF, 620 KB

english, 2004

17

1.C.3 Use of transgenic animal models to study enzymes involved in lipoprotein metabolism and atherosclerosis

Silvia Santamarina-Fojo

Journal:

Atherosclerosis

Year:

1997

Language:

english

File:

PDF, 186 KB

english, 1997

18

1.P.77 Correction of hypoalphalipoproteinemia in LDL receptor deficiency by lecithin: cholesterol acyltransferase (LCAT)

M.E. Brousseau, J. Wang, S.J. Demosky Jr., B.L. Vaisman, S. Santamarina-Fojo, H.B. Brewer Jr., J.M. Hoeg

Journal:

Atherosclerosis

Year:

1997

Language:

english

File:

PDF, 358 KB

english, 1997

19

Role of hepatic lipase in lipoprotein metabolism and atherosclerosis

S. Santamarina-Fojo, M. Amar, C. Haudenschild, K. Dugi, H.B. Brewer Jr.

Journal:

Atherosclerosis

Year:

1999

Language:

english

File:

PDF, 154 KB

english, 1999

20

Lcat overexpression in different animal models: modulation of atherosclerosis by CETP, HL and apoA-1

S. Santamarina-Fojo, J. Hoeg, B. Vaisman, M. Amar, B. Foger, M. Brousseau, C. Koch, B. Paigen, S. Marcovina, H.B. Brewer Jr.

Journal:

Atherosclerosis

Year:

1999

Language:

english

File:

PDF, 300 KB

english, 1999

21

4.P.363 Two novel mutations of cholesteryl ester transfer protein (CETP) gene in Japanese hyperalphalipoproteinemic patients

Sakai, N., Arai, T., Maruyama, T., Yamashita, S., Santamarina-Fojo, S., Brewer, H.B., Matsuzawa, Y.

Journal:

Atherosclerosis

Year:

1997

Language:

english

File:

PDF, 168 KB

english, 1997

22

THE FAMILIAL CHYLOMICRONEMIA SYNDROME

Santamarina-Fojo, Silvia

Journal:

Endocrinology and Metabolism Clinics of North America

Year:

1998

Language:

english

File:

PDF, 1.06 MB

english, 1998

23

Medical News.

Santamarina-Fojo, Silvia

Journal:

Year:

1882

Language:

english

File:

PDF, 398 KB

english, 1882

24

Th-W57:5 Decreased plasma apoB-containing lipoprotein and atherosclerosis in ABCG5/G8 X LDLR-KO mice on ezetimibe

Basso, F., Freeman, L., Ko, C., Tansey, T., Amar, M.J., Thomas, F., Santamarina-Fojo, S., Brewer, H.B.

Journal:

Atherosclerosis Supplements

Year:

2006

Language:

english

File:

PDF, 156 KB

english, 2006

25

4WS26-1 The role of ABC transporters in atherosclerosis; Studies in transgenic mouse models

Santamarina-Fojo, S., Joyce, C., Wu, J., Basso, F., Najib-Fruchart, J., Paigen, B., Brewer, H.B.

Journal:

Atherosclerosis Supplements

Year:

2003

Language:

english

File:

PDF, 59 KB

english, 2003

26

4.P.362 Lecithin: Cholesterol acyltransferase (LCAT) knockout mice: A new animal model for human LCAT-deficiency

Sakai, N., Vaisman, B.L., Koch, C.A., Hoyt, R.F., Meyn, S.M., Paiz, J.A., Brewer, H.B., Santamarina-Fojo, S.

Journal:

Atherosclerosis

Year:

1997

Language:

english

File:

PDF, 308 KB

english, 1997

27

Overexpression of Lecithin:Cholesterol Acyltransferase in Transgenic Rabbits Prevents Diet-Induced Atherosclerosis

Jeffrey M. Hoeg, Silvia Santamarina-Fojo, Annie M. Bérard, J. Fredrick Cornhill, Edward E. Herderick, Sanford H. Feldman, Christian C. Haudenschild, Boris L. Vaisman, Robert F. Hoyt, Stephen J. Demosk

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.58 MB

english, 1996

28

Plasma Phospholipid Transfer Protein: ADENOVIRUS-MEDIATED OVEREXPRESSION IN MICE LEADS TO DECREASED PLASMA HIGH DENSITY LIPOPROTEIN (HDL) AND ENHANCED HEPATIC UPTAKE OF PHOSPHOLIPIDS AND CHOLESTERYL ESTERS FROM HDL

Foger, B., Santamarina-Fojo, S., Shamburek, R. D., Parrot, C. L., Talley, G. D., Brewer, H. B.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 807 KB

english, 1997

29

Human Hepatic and Lipoprotein Lipase: The Loop Covering the Catalytic Site Mediates Lipase Substrate Specificity

Dugi, K. A., Dichek, H. L., Santamarina-Fojo, S.

Journal:

Journal of Biological Chemistry

Year:

1995

Language:

english

File:

PDF, 124 KB

english, 1995

30

Cholesteryl Ester Transfer Protein Corrects Dysfunctional High Density Lipoproteins and Reduces Aortic Atherosclerosis in Lecithin Cholesterol Acyltransferase Transgenic Mice

Foger, B., Chase, M., Amar, M. J., Vaisman, B. L., Shamburek, R. D., Paigen, B., Fruchart-Najib, J., Paiz, J. A., Koch, C. A., Hoyt, R. F., Brewer, H. B., Santamarina-Fojo, S.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 727 KB

english, 1999

31

The ABCA1 Transporter Modulates Late Endocytic Trafficking: INSIGHTS FROM THE CORRECTION OF THE GENETIC DEFECT IN TANGIER DISEASE

Neufeld, E. B., Stonik, J. A., Demosky, S. J., Knapper, C. L., Combs, C. A., Cooney, A., Comly, M., Dwyer, N., Blanchette-Mackie, J., Remaley, A. T., Santamarina-Fojo, S., Brewer, H. B.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 1.40 MB

english, 2004

32

Targeted Disruption of the Mouse Lecithin:Cholesterol Acyltransferase (LCAT) Gene: GENERATION OF A NEW ANIMAL MODEL FOR HUMAN LCAT DEFICIENCY

Sakai, N., Vaisman, B. L., Koch, C. A., Hoyt, R. F., Meyn, S. M., Talley, G. D., Paiz, J. A., Brewer, H. B., Santamarina-Fojo, S.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 807 KB

english, 1997

33

Overexpression of Human Lecithin Cholesterol Acyltransferase Leads to Hyperalphalipoproteinemia in Transgenic Mice

Vaisman, B. L., Klein, H.-G., Rouis, M., rard, A. M. B., Kindt, M. R., Talley, G. D., Meyn, S. M., Hoyt, R. F., Marcovina, S. M., Albers, J. J., Hoeg, J. M., Brewer, H. B., Santamarina-Fojo, S.

Journal:

Journal of Biological Chemistry

Year:

1995

File:

PDF, 3.25 MB

1995

34

Cellular Localization and Trafficking of the Human ABCA1 Transporter

Neufeld, E. B., Remaley, A. T., Demosky, S. J., Stonik, J. A., Cooney, A. M., Comly, M., Dwyer, N. K., Zhang, M., Blanchette-Mackie, J., Santamarina-Fojo, S., Brewer, H. B.

Journal:

Journal of Biological Chemistry

Year:

2001

Language:

english

File:

PDF, 3.08 MB

english, 2001

35

The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice

Joyce, C. W., Amar, M. J. A., Lambert, G., Vaisman, B. L., Paigen, B., Najib-Fruchart, J., Hoyt, R. F., Neufeld, E. D., Remaley, A. T., Fredrickson, D. S., Brewer, H. B., Santamarina-Fojo, S.

Journal:

Proceedings of the National Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 271 KB

english, 2002

36

Hepatic ABCG5 and ABCG8 Overexpression Increases Hepatobiliary Sterol Transport but Does Not Alter Aortic Atherosclerosis in Transgenic Mice

Wu, J. E., Basso, F., Shamburek, R. D., Amar, M. J. A., Vaisman, B., Szakacs, G., Joyce, C., Tansey, T., Freeman, L., Paigen, B. J., Thomas, F., Brewer, H. B., Santamarina-Fojo, S.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 1.08 MB

english, 2004

37

Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited

Basso, F., Freeman, L. A., Ko, C., Joyce, C., Amar, M. J., Shamburek, R. D., Tansey, T., Thomas, F., Wu, J., Paigen, B., Remaley, A. T., Santamarina-Fojo, S., Brewer, H. B.

Journal:

The Journal of Lipid Research

Year:

2006

Language:

english

File:

PDF, 539 KB

english, 2006

38

Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mice

Freeman, L., Amar, M. J. A., Shamburek, R., Paigen, B., Brewer, H. B., Santamarina-Fojo, S., Gonzalez-Navarro, H.

Journal:

The Journal of Lipid Research

Year:

2006

Language:

english

File:

PDF, 314 KB

english, 2006

39

The Familial Hyperchylomicronemia Syndrome

Santamarina-Fojo, Silvia

Journal:

JAMA The Journal of the American Medical Association

Year:

1991

Language:

english

File:

PDF, 4.16 MB

english, 1991

40

Complete genomic sequence of the human ABCA1 gene: Analysis of the human and mouse ATP-binding cassette A promoter

Santamarina-Fojo, S., Peterson, K., Knapper, C., Qiu, Y., Freeman, L., Cheng, J.-F., Osorio, J., Remaley, A., Yang, X.-P., Haudenschild, C., Prades, C., Chimini, G., Blackmon, E., Francois, T., Duverg

Journal:

Proceedings of the National Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 254 KB

english, 2000

41

In Vivo Evidence for Both Lipolytic and Nonlipolytic Function of Hepatic Lipase in the Metabolism of HDL

Dugi, K. A., Amar, M. J. A., Haudenschild, C. C., Shamburek, R. D., Bensadoun, A., Hoyt, R. F., Fruchart-Najib, J., Madj, Z., Brewer, H. B., Santamarina-Fojo, S.

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

2000

Language:

english

File:

PDF, 636 KB

english, 2000

42

LCAT Modulates Atherogenic Plasma Lipoproteins and the Extent of Atherosclerosis Only in the Presence of Normal LDL Receptors in Transgenic Rabbits

Brousseau, M. E., Kauffman, R. D., Herderick, E. E., Demosky, S. J., Evans, W., Marcovina, S., Santamarina-Fojo, S., Brewer, H. B., Hoeg, J. M.

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

2000

Language:

english

File:

PDF, 654 KB

english, 2000

43

Familial HDL deficiency due to marked hypercatabolism of normal apoA-I

Emmerich, J., Verges, B., Tauveron, I., Rader, D., Santamarina-Fojo, S., Shaefer, J., Ayrault-Jarrier, M., Thieblot, P., Brewer, H. B.

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

1993

Language:

english

File:

PDF, 4.32 MB

english, 1993

44

Lecithin-cholesterol acyltransferase: role in lipoprotein metabolism, reverse cholesterol transport and atherosclerosis

Santamarina-Fojo, Silvia, Lambert, Gilles, Hoeg, Jeffrey M., Brewer, H. Bryan

Journal:

Current Opinion in Lipidology

Year:

2000

Language:

english

File:

PDF, 233 KB

english, 2000

45

Genetic dyslipoproteinemias: role of lipoprotein lipase and apolipoprotein C-ll

Santamarina-Fojo, Silvia

Journal:

Current Opinion in Lipidology

Year:

1992

File:

PDF, 797 KB

1992

46

Therapeutic Response to Medium-Chain Triglycerides and Ï-3 Fatty Acids in a Patient With the Familial Chylomicronemia Syndrome

Rouis, Mustapha, Dugi, Klaus A., Previato, Lorenzo, Patterson, Amy P., Brunzell, John D., Brewer, H. Bryan, Santamarina-Fojo, Silvia

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

1997

File:

PDF, 868 KB

1997

47

Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis.

Hoeg, J. M., Santamarina-Fojo, S., Berard, A. M., Cornhill, J. F., Herderick, E. E., Feldman, S. H., Haudenschild, C. C., Vaisman, B. L., Hoyt, R. F., Demosky, S. J., Kauffman, R. D., Hazel, C. M., Ma

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

File:

PDF, 1.70 MB

1996